Title:Dosage Form Developments of Nanosuspension Drug Delivery System for Oral Administration Route
Volume: 21
Issue: 29
Author(s): Ang Chen, Ye Shi, Zhiqiang Yan, Hongxun Hao, Yong Zhang, Jian Zhong and Huiming Hou
Affiliation:
Keywords:
Administration route, dosage form, drug delivery system, nanosuspension, oral administration.
Abstract: A large amount of new drug candidates are practically insoluble in aqueous solvents and are even simultaneously poorly soluble
in organic solvents. Nanosuspension drug delivery system (DDS) was firstly developed in 1994 and has attracted more and more attention
as a formation solution for the poorly soluble drugs. By nansizing the poorly soluble drugs, nanosuspensions have several outstanding
advantages for drug delivery. Among many administration routes of drug delivery, oral administration is the most preferred
route due to its advantages such as ease of ingestion, versatility to accommodate various types of drug candidates, low production cost,
high safety, good patient compliance, and pain avoidance. Current marketed pharmaceutical nanosuspension DDS products are mostly
for oral administration. This review is to systematically summarize the nanosuspension DDS dosage form developments of poorly soluble
drugs for oral administration use.
