Title:Angiotensin II and Abdominal Aortic Aneurysms: An update
Volume: 21
Issue: 28
Author(s): Jing Liu, Alan Daugherty and Hong Lu
Affiliation:
Keywords:
Abdominal aortic aneurysms, mechanisms, angiotensin, inflammation, mouse.
Abstract: Abdominal aortic aneurysm (AAA) is a devastating disease associated with high prevalence of death due
to aortic rupture. Currently the therapy is restricted to surgical procedures to prevent aortic rupture, which in turn
has a risk for postoperative mortality. There are no proven pharmacological therapies available to prevent expansion
or rupture of AAA due to the paucity of knowledge on the mechanisms underlying the nature and pathophysiological
processes of this complex disease. Animal models are powerful tools to provide mechanistic insights into
understanding the development of AAA. Numerous pharmacological approaches have been explored as potential
therapies in experimental AAA in the past decade. This review overviews recent advances in mechanistic studies of
AAA in angiotensin II-infused mouse models and highlights their clinical relevance for possible therapeutic targets.
