Title:Nutrition, Nitrogen Requirements, Exercise and Chemotherapy-Induced Toxicity in Cancer Patients. A puzzle of Contrasting Truths?
Volume: 16
Issue: 1
Author(s): Vincenzo Flati, Giovanni Corsetti, Evasio Pasini, Anna Rufo, Claudia Romano and Francesco Saverio Dioguardi
Affiliation:
Keywords:
Amino acids, cancer, chemotherapy, heart doxorubicin, mTOR, nutrition, exercise.
Abstract: Amino acids can modulate cell metabolism and control cell fate by regulating cell survival and cell
death. The molecular mechanisms involved are mediated by the mTOR complexes mTORC1 and mTORC2
activity. These complexes are finely regulated and the continuous advancement of the knowledge on their
composition and function is revealing that their balance may represent the condition that determines the cell fate.
This is important for normal healthy cells but it is becoming clear, and it is even more important, that the balance
of the mTORCs activity may also condition the cell fate of cancer cells. Here, we discuss the evidences supporting
the amino acids supplementation as a cancer fighting weapon and a possible strategy to counteract the myocyte toxicity associated with
chemotherapy, possibly by tipping the balance of mTORCs activity.
