Title:Cyclodextrin-Based Delivery Systems for Arthritic Diseases: From Development to Experimental Therapeutics
Volume: 21
Issue: 33
Author(s): Monica Helena Monteiro Nascimento, Alessandra Cristina Santos Akkari, Kelly Cristina Freitas Mariano, Antonio Sergio Kimus Braz, Christiane Bertachini Lombello and Daniele Ribeiro de Araujo
Affiliation:
Keywords:
Arthritic diseases, cyclodextrins, drug-conjugate polymers, drug-delivery systems, inclusion complex, osteoarthritis,
pseudorotaxanes, rheumathoid arthritis.
Abstract: Arthritics diseases, such as rheumatoid arthritis and osteoarthritis are chronic inflammatory and one of
the most prevalent health conditions that cause disability (pain and functional limitation of joints). Despite the research
advances, the treatment of those pathological conditions remains ineffective, since the pharmacological therapy
is palliative, reducing only the symptoms and, in some cases, the chronic progression of the disease. In this
context, the development of new formulations for controlled release would be interesting for reducing the number
of injections and would also increase the patient compliance. In this article, we present a review of the cyclodextrin
(CD)-based delivery systems focusing from conventional guest-host inclusion complexes and CD-polysulphates,
until supramolecular architectures such as drug-CD-polymers conjugates, pseudorotaxanes, hydrogels as well as
double-carrier systems and other systems. In particular, this article focuses the main CD-based delivery systems described
in the literature emphasizing their possible administration by intra-articular route on the treatment of arthritic diseases, concentrating
on their development and also performance as in vivo experimental therapeutic systems.
