Title:The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option
Volume: 13
Issue: 6
Author(s): Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Domenico Pirritano, Aida Squillace, Giovambattista De Sarro and Luca Gallelli
Affiliation:
Keywords:
Cocaine dependence, gamma-aminobutyric acid neurotransmission, glutamatergic neurotransmission, topiramate.
Abstract: Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and
psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits
glutamatergic transmission (i.e. AMPA/kainate receptors).
Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine
reinforcement. Therefore, TPM could be used in the management of cocaine dependence.