Title:Genetic Polymorphisms Might Predict Suicide Attempts in Mental Disorder Patients: A Systematic Review And Meta-Analysis
Volume: 14
Issue: 7
Author(s): Veronica de Medeiros Alves, Daniele Goncalves Bezerra, Tiago Gomes de Andrade, Valfrido Leao de Melo Neto and Antonio E. Nardi
Affiliation:
Keywords:
Candidate gene, polymorphism, serotonin, suicidal behavior.
Abstract: The aim of the present study was to analyze if the genetic polymorphisms might predict
suicide attempts in mental disorder patients. The literature review and meta-analysis were conducted
using the PubMed/Medline, Web of science and Scopus database using the terms: “5-HTT or SLC6A4
or 5-SERT and suicide, suicidal ideation or suicidal behavior or suicidal attempt”. Thirty articles were
analyzed. We found 17 articles that showed association and 13 articles that showed no association
between LPR serotonin transporter polymorphism and suicide. A higher study of suicide identified the serotonin
transporter polymorphism in patients with schizophrenia, mental disorder, major depression and bipolar disorder. There is
an association between the serotonin-transporter-linked polymorphic region and suicidal behavior. The mental disorders
with greater relationship with the suicide were the bipolar disorder, major depression and schizophrenia. The L allele had
higher risk for suicide.
