Title:Recent Advances in Liposomal Drug Delivery: A Review
Volume: 3
Issue: 1
Author(s): Vijaykumar Nekkanti and Sandeep Kalepu
Affiliation:
Keywords:
Liposomes, immunoliposomes, proteins and peptides, vaccines, gene delivery, active
targeting.
Abstract: Since the discovery of liposomes, the drug delivery technology has made a
tremendous advancement in the field of medicine. Owing to their biocompatibility, efficacy,
targeting ability and improved in vivo performance, liposomes has become popular as
versatile drug carrier systems. Controlled and sustained drug release, lowered systemic
toxicity and improved pharmacokinetic and pharmacodynamic properties of drug are the potential
applications of liposomal drug delivery. Drugs encapsulated in liposomes can be targeted actively and
passively to the tumor specific site with improved efficacy and reduced off-target effects. Development of
multifunctional liposomes for targeting cell organelles, long acting (PEGylated) and with combination of
drugs is a hot-topic of current research. In recent years, the focus of liposomal technology has been on the
combined applications of diagnostics and therapeutics. The present work reviews the liposomal drug delivery
field, summarizes the success of liposomal technology in translation from concept to clinical acceptance and
recent developments in the delivery of anti-fungal, antibiotic, anti-inflammatory and anti-cancer drugs.
