Glucan Particles Loaded with Fluorinated Emulsions: A Sensitivity Improvement for the Visualization of Phagocytic Cells by ¹⁹F-MRI

Title:Glucan Particles Loaded with Fluorinated Emulsions: A Sensitivity Improvement for the Visualization of Phagocytic Cells by ¹⁹F-MRI

Volume: 4 Issue: 1

Author(s): Cristina Chirizzi, Walter Dastrù, Daniela D. Castelli, Valeria Menchise, Silvio Aime and Enzo Terreno

Affiliation:

Keywords: ¹⁹F-MRI, cellular imaging, glucan particles, macrophages, theranosis, perfluorocarbons.

Abstract: A protocol to load perfluoro-crown-ether (PFCE) nanoemulsion directly into yeast-derived glucan particles (GPs) was developed. It was observed that the PFCE encapsulation did not affect the ¹⁹F-MRI properties of the nanoemulsion that is currently in clinical trials. GPs loaded with PFCE nanoemulsion were taken up avidly by murine macrophages in vitro, resulting in a cellular uptake 150 % higher than the not GPs-entrapped nanoemulsion. Accordingly, a corresponding improvement in the ¹⁹F-MRI detection of the labelled cells can be obtained. The high biotolerability and versatility of GPs, make these microcarriers a promising option for designing of improved in vivo cellular imaging protocols.

Cite this article as:

Chirizzi Cristina, Dastrù Walter, D. Castelli Daniela, Menchise Valeria, Aime Silvio and Terreno Enzo, Glucan Particles Loaded with Fluorinated Emulsions: A Sensitivity Improvement for the Visualization of Phagocytic Cells by ¹⁹F-MRI, Current Molecular Imaging (Discontinued) 2015; 4 (1) . https://dx.doi.org/10.2174/2211555204666150702160805

DOI https://dx.doi.org/10.2174/2211555204666150702160805	Print ISSN 2211-5552
Publisher Name Bentham Science Publisher	Online ISSN 2211-5544