Title:Therapeutic Angiogenesis in Ischemic Tissues by Growth Factors and Bone Marrow Mononuclear Cells Administration: Biological Foundation and Clinical Prospects
Volume: 10
Issue: 6
Author(s): Dmitry Bulgin
Affiliation:
Keywords:
Bone marrow mononuclear cells, growth factors, ischemic tissues regeneration, therapeutic angiogenesis.
Abstract: The processes of new vessels formation in tissues are supported by two definite mechanisms:
de novo development of blood vessels (vasculogenesis) through the accumulation of progenitor
cells during early prenatal stage, and extension of a pre-existing microcirculatory network by endothelial
cell germination (angiogenesis), the essential mechanism of blood vessel formation in postnatal period.
Angiogenesis is associated with a series of inductive, permissive and restrictive communications
that result in the appearance, differentiation, and formation of new vessels. The goal of therapeutic angiogenesis
is to improve blood circulation, relay survival factors and regenerative stem cell populations
to sites of tissue repair, and ultimately recover function and form of the tissue. Growth factors
and bone marrow mononuclear cells represent a very interesting research field for the realization of
therapeutic angiogenesis in ischemic tissues. They provide a potential key component in the healing
processes of ischemic injured tissues.
