Title:The Challenge of a “Functional Cure” for AIDS by Gene Modified HSCT Therapy
Volume: 10
Issue: 6
Author(s): Lei Xu, Hu Chen and Bin Zhang
Affiliation:
Keywords:
CCR5/CXCR4, functional cure, gene mutation, gene therapy, HIV/AIDS, HSCT.
Abstract: Acquired immunodeficiency syndrome (AIDS), an infectious disease which is difficult to be
cured, is regularly and effectively treated with anti-retroviral therapy in clinic. When considering about
the defects of antiretroviral therapy (ART), patients need a new way to cure AIDS. With the development
of genetic engineering technology and humanized mouse models, a new way has been found to achieve a
“functional cure” for AIDS. One/some specific gene(s), such as CCR5 and CXCR4, can be knocked out
to produce HIV-resisting cells, so as to achieve the purpose of curing AIDS. To find a safe and effective
therapy for AIDS, treatment strategy and technical scheme should be improved and optimized in
many aspects. Moreover, different stages of works have been done in laboratory and in clinic based on this gene mutation
strategy. However, a great deal of challenge has emerged while great progress has been made. Safety considerations and effectiveness
of gene modified stem cell in clinic are major obstacles of the application of this strategy.
