Title:Therapy Stratifications and Novel Approach in Pursuit of Aids Related Kaposi’s Sarcoma Management- A paradigm for Non Invasiveness
Volume: 12
Issue: 6
Author(s): Meenu Sharma, Vijay Sharma and Kamla Pathak
Affiliation:
Keywords:
HIV, HHV-8 virus, Kaposi’s sarcoma, Non-invasive, Pathogenesis, Transferosomes.
Abstract: Cancer in individuals suffering with HIV and AIDS has become a common source of morbidity
and mortality, especially in the underdeveloped world in which Kaposi’s sarcoma is the most
occurring tumor of vascular endothelium frequently seen in patients suffering from AIDS. Suffering
individuals are invariably co-infected with HIV and HHV-8 virus. The conventional modes for chemotherapies
may be clinically useful in patients with Kaposi’s sarcoma. Though advancements in
treatment modalities of AIDS related Kaposi’s sarcoma have been successfully achieved, till date an
exclusive therapy of golden standard has not been principally defined that can deliver the drug via
non-invasive route. Novel concepts of treatment primarily address the factors that are associated with
the pathogenesis of critical disease. On the other hand local therapies are aimed at eradicating primary lesions; and systemic
chemotherapies are aimed to treat widespread visceral involvement. Increased understanding of the mechanisms
underlying viral tumorigenesis will hopefully portray new therapeutic strategies. This review discusses novel drug delivery
strategies that have been investigated for the effective and safe management of AIDS related kaposi’s sarcoma. The
review also highlights, the lipid based ultradeformable vesicular system that offers attractive drug delivery platform capable
of delivering its payload without using invasive technique. These systems offer advance models for efficacious treatment
of the future therapy aiming Kaposi’s sarcoma.
