Title:Anxiolytic-Like Effects of 7H-Benzo[e]perimidin-7-One Derivatives through Elevated Plus-Maze Test in Mice
Volume: 15
Issue: 17
Author(s): Jorge Nunez, Jose A. Fontenla, Seyed Mohammad Nabavi, Eugenio Uriarte, Alejandra Herrera and Eduardo Sobarzo-Sanchez
Affiliation:
Keywords:
7H-benzo[e]perimidin-7-one, Anxiety, Depression, Oxoisoaporphines, Perimidinones, Plus-maze test.
Abstract: Anxiety is one of the behavior disorders that has been studied more together with depression
in the world, and that has enormous interference in the mental health of the affected patients. The
states of panic and phobia are a part of the psychological characteristics that some drugs have tried to control though with
varied side effects that are proven to be difficult to control. The use of perimidinone derivatives against the effects of
anxiety has generated that A5 is the most active and selective anxiolytic compound, differing with regard to diazepam
(DZP) used as control reference in elevated plus-maze (EPM) test. This test allows to conclude that it is feasible to differentiate
the use selective as anxiolytic or antidepressant of certain perimidinones, because A4 had been characterized by
our research group as an important antidepressant respect to A5 studied in previous reports.
