Title:Alternative Splicing, DNA Damage and Modulating Drugs in Radiation Therapy for Cancer
Volume: 15
Issue: 6
Author(s): Jen-Yang Tang, Ruei-Nian Li, Ping-Ho Chen, Hurng-Wern Huang, Ming-Feng Hou and Hsueh-Wei Chang
Affiliation:
Keywords:
Alternative splicing, DNA damage, radiation.
Abstract: Radiotherapy effectively destroys cancer cells in many sites of the body, but several limitations remain. This study
investigated alternative splicing, which is a common mechanism of increased diversity in mRNAs and proteins. The relationships of
alternative splicing to DNA damage and radiation such as UV and ionizing radiation were analyzed. The DNA damage responses of
many genes involved in alternative splicing were compared between non-radiation and radiation treatments. Drugs that affect
radioresistence or radiosensitization by modulating the effects of alternative splicing and radiation were also reviewed.
