Title:Neuropharmacological Aspects of Crocus sativus L.: A Review of Preclinical Studies and Ongoing Clinical Research
Volume: 14
Issue: 7
Author(s): Damanpreet Singh
Affiliation:
Keywords:
Alzheimer's disease, cognition deficit, crocin, Crocus sativus L. (Iridaceae), depressive disorders, neurosensory,
neurotoxicity.
Abstract: Crocus sativus L. (Iridaceae) is an important member of the genus Crocus having high
medicinal value. Its dried stigmas, known as “saffron” are being widely used form past many centuries
as a food additive, coloring agent, flavoring agent and a potential source of traditional medicine. The
stigmas along with other botanical parts of Crocus sativus are being extensively used in ethnomedical
treatment of varied central nervous system diseases. In line with its ethnomedical importance, several
preclinical studies have been carried out to validate its traditional uses, identify active principle(s),
understand pharmacological basis of therapeutic action and explore novel medicinal uses. The
bioactive components of Crocus sativus have been found to modulate several synaptic processes via direct/indirect
interplay with neurotransmitter receptor functions, interaction with neuronal death/survival pathways and alteration in
neuronal proteins expression. Many clinical studies proving beneficial effect of Crocus sativus in depressive disorders,
Alzheimer's disease and some other neurological abnormalities have also been carried out. Based on the vast literature
reports available, an attempt has been made to comprehend the fragmented information on neuropharmacological aspects,
chemistry and safety of Crocus sativus. Although the plant has been well explored, but still a large scope of future
preclinical and clinical research exist to explore its potential in neurological diseases, that has been discussed in depth in
the present review.
