Title:Anti-Cancer Cytotoxic Effects of Multiwalled Carbon Nanotubes
Volume: 21
Issue: 15
Author(s): Lorena Garcia-Hevia, Rafael Valiente, Jesus Gonzalez, Jose Luis Fernandez-Luna, Juan C. Villegas and Monica L. Fanarraga
Affiliation:
Keywords:
MWCNTs, tubulin, microtubule dynamics, cell death, chemotherapy.
Abstract: Recent research has opened new alternatives to traditional chemotherapy treatments using nanomaterials
as cytotoxic agents. Anti-cancer nanomedicines do not require specific target sites on key proteins or genes to
kill cancer cells and have radically different mechanisms to interact with the living matter. Among 1D nanomaterials,
multiwalled carbon nanotubes (MWCNTs) have the intrinsic ability to bind tubulin and interfere with microtubule
dynamics, mimicking the effect of traditional cytotoxic microtubule-binding agents such as paclitaxel
(taxol®). Here, we review the cytotoxic properties of MWCNTs and show a direct pro-apoptotic effect of these
nanomaterials in vitro in different cancer cell lines and tumor cells obtained from surgical specimens. Understanding
the bio-synthetic relationship between MWCNTs and microtubules could serve to improve these nanomaterials
to be used as broad spectrum antineoplastic agents in combination to traditional microtubule-binding treatments,
thus avoiding drug resistance mechanisms in cancer cells.
