Title:Development and Optimization of Solid Self Nanoemulsifying Drug Delivery (S-SNEDDS) Using D-Optimal Design for Improvement of Oral Bioavailability of Amiodarone Hydrochloride
Volume: 12
Issue: 6
Author(s): Archita Patel, Pragna Shelat and Anita Lalwani
Affiliation:
Keywords:
Amiodarone hydrochloride, Bioavailability, L-SNEDDS, S-SNEDDS.
Abstract: The solid-self nanoemulsifying drug delivery system (S-SNEDDS) of Amiodarone hydrochloride
(AH) was prepared and evaluated. AH exhibits poor aqueous solubility (0.3-0.5 mg/ml) and
therefore variable oral bioavailability. Capmul MCM, Cremophor RH-40 and Propylene glycol were
identified as oil, surfactant and co-surfactant for preparing L-SNEDDS. D-optimal design was used
to optimize the amount of components in liquid self nanoemulsifying drug delivery system
(L-SNEDDS). Optimized AH-L-SNEDDS having 15.8 nm globule size and 99.5 %transmittance was
then adsorbed on Neusilin US2 to form solid self nanoemulsifying drug delivery system (AH-SSNEDDS).
AH loaded L-SNEDDS and S-SNEDDS were characterized for various physicochemical properties and solid
state properties. In vitro dissolution, ex vivo drug release study and In vivo study were performed for pure AH, AH-LSNEDDS
and AH-S-SNEDDS. Both AH loaded L-SNEDDS and S-SNEDDS showed more than 95% drug release in 20
min during drug release studies. In vivo study revealed that release of AH from S-SNEDDS was 2.26 times and LSNEDDS
was 1.83 times higher than that from suspension when given to rabbits (p < 0.01). The optimized S-SNEDDS
was found to be stable and its shelf life was found to be 2.2 years. S-SNEDDS could serve as a potential drug delivery
system for AH.
