Title:Computational Drug Repositioning for Cancer Therapeutics
Volume: 15
Issue: 8
Author(s): Mingkun Jiao, Gang Liu, Yu Xue and Chunyong Ding
Affiliation:
Keywords:
Anticancer drugs, Cancer therapeutics, Computational drug repositioning, Drug discovery, Drug repositioning,
Drug repurposing.
Abstract: Due to ever-increasing failure rates, high cost, unsatisfactory safety profile, and limited efficacy
associated with anticancer drug development, the repositioning of established non-cancer drugs for
new oncology indications has emerged as an increasingly attractive approach to addressing the unmet
cancer-related medical need. With the rapid development of bioinformatics, chemoinformatics as well
as high-performance computing, drug repositioning is becoming more intentional than ever, and a significant
surge of computational approaches has been well established to greatly facilitate drug repositioning
for cancer treatment. In this review, we provide a brief overview of recent advances in the computational
drug repositioning for anticancer applications with a specific emphasis on repositioning of non-cancer drugs by
use of various computational approaches.
