Title:The Processing of Chitosan and Its Derivatives and Their Application for Postoperative Anti-Adhesion
Volume: 15
Issue: 4
Author(s): Lin Zhu, Lin Peng and Yu-Qing Zhang
Affiliation:
Keywords:
Chitosan, carboxymethyl chitosan, postoperative peritoneal anti-adhesion.
Abstract: The formation of peritoneal adhesions represents one of the most common complications
after abdominal surgery, and it increases the difficulty of re-operation. Thus, preventing postoperative
adhesions is a major problem in the field of surgical medicine. Due to a lack of good predictive animal
models and the complexity of adhesion pathogenesis, attempts to prevent or reduce peritoneal
adhesions have been largely unsuccessful. As a result, the study of anti-adhesion drugs and materials
has become a hot topic for experts and scholars. The processing and development of chitosan and its
derivatives as new anti-adhesion materials is highly valued because chitosan is inexpensive, highly biocompatible, and not
cytotoxic, making it a promising anti-adhesion material. Here, we review the sources and preparation of chitosan and the
progress made toward producing different types of chitosan and its derivatives for preventing adhesion.
