Title:Multitarget Network Strategies to Influence Memory and Forgetting: The Ras/Mapk Pathway as a Novel Option
Volume: 15
Issue: 8
Author(s): Marton David Gyurko, Attila Stetak, Csaba Soti and Peter Csermely
Affiliation:
Keywords:
Learning, memory, molecular networks, neurodegenerative disorders, Ras/MAPK, RASopathies.
Abstract: The Ras/mitogen activated protein kinase (MAPK) pathway has key importance in
development, cell differentiation and senescence, tumorigenesis, learning and memory. The clinical
manifestations associated with this highly conserved pathway are called RASopathies. Phenotypic
features are diverse and overlapping, but cognitive impairment is a common symptom. Here, we
propose an approach based on molecular networks that link learning, memory and forgetting to the
RASopathies and various neurodegenerative and neurodevelopmental diseases such as Alzheimer's
disease, Parkinson's disease and autism spectrum disorders. We demonstrate the cross-talks of the molecular pathways in
RASopathies and memory and the role of compartmentalization in these processes. The approved drugs are also overviewed,
and C. elegans is proposed as a viable model system for experimental exploration and compound target prediction.n
