Title:Streptokinase-A Drug for Thrombolytic Therapy: A Patent Review
Volume: 9
Issue: 2
Author(s): Adinarayana Kunamneni and Ravi Durvasula
Affiliation:
Keywords:
Acute myocardial infarction (AMI), fibrinolysis, plasminogen activators, streptokinase (SK), thrombolytic therapy.
Abstract: Accumulation of fibrin in blood vessels significantly increases thrombosis, leading to myocardial
infraction and other cardiovascular diseases. Microbial enzymes are one option for curing this
pathological condition. Fibrinolytic enzymes such as urokinase (UK), tissue type plasminogen activator
(t-PA) and streptokinase (SK) attracted much attention for thrombolytic therapy. Among them SK
is preferable in low-resource settings because it is cost-effective. Therefore, the purpose of this review is to summarize
recent patents related to the occurrence, mechanism of action, physico-chemical properties, cloning and expression, production,
structure, immunogenicity, chemical modification, in vivo application and clinical trials of SK. This patent review
considers the properties and characteristics of SK that make it a preferred agent for thrombolytic therapy.
