Title:Systemic Drug Delivery Systems for Bone Tissue Regeneration– A Mini Review
Volume: 21
Issue: 12
Author(s): Wang Xinluan, Lai Yuxiao, Ng HueiLeng Helena, Yang Zhijun and Qin Ling
Affiliation:
Keywords:
Bone-targeting, systemic drug delivery system, liposomes, nanoparticles.
Abstract: Musculoskeletal metabolic diseases such as osteoporosis have become the major public health problems worldwide
in our aging society. Pharmaceutical therapy is one of the approaches to prevent and treat related medical conditions. Most of the clinically
used anti-osteoporotic drugs are administered systemically and have demonstrated some side effects in non-skeletal tissues. One of
the innovative approaches to prevent potential adverse effects is the development of bone-targeting drug delivery technologies that not
only minimizes the systemic toxicity but also improves the pharmacokinetic profile and therapeutic efficacy of chemical drugs. This paper
reviews the currently available bone targeting drug delivery systems with emphasis as bone-targeting moieties, including the bonesurface-
site-specific (bone formation dominant or bone resorption dominant) and cell-specific moieties. In addition, the connections of
drug-bone-targeting moieties-carrier are also summarized, and the newly developed liposomes and nanoparticles are discussed for their
potential use and main challenges in delivering therapeutic agents to bone tissue. As a rapid-developing biotechnology, systemic bonetargeting
delivery system is promising but still in its infancy where challenges are ahead of us, including the stability and the toxicity issues,
especially to fulfill the regulatory requirement to realize bench-to-bedside translation. Newly developed biomaterials and technologies
with potential for safer and more effective drug delivery require multidisciplinary collaborations with preclinical and clinical scientists
that are essential to facilitate their clinical applications.
