Title:3D Printing Technology Over a Drug Delivery for Tissue Engineering
Volume: 21
Issue: 12
Author(s): Jin Woo Lee and Dong-Woo Cho
Affiliation:
Keywords:
3D printing, biomolecule, drug delivery system (DDS), scaffold, tissue engineering.
Abstract: Many researchers have attempted to use computer-aided design (CAD) and computer-aided manufacturing (CAM)
to realize a scaffold that provides a three-dimensional (3D) environment for regeneration of tissues and organs. As a result,
several 3D printing technologies, including stereolithography, deposition modeling, inkjet-based printing and selective laser
sintering have been developed. Because these 3D printing technologies use computers for design and fabrication, and they can
fabricate 3D scaffolds as designed; as a consequence, they can be standardized. Growth of target tissues and organs requires the presence
of appropriate growth factors, so fabrication of 3Dscaffold systems that release these biomolecules has been explored. A drug delivery
system (DDS) that administrates a pharmaceutical compound to achieve a therapeutic effect in cells, animals and humans is a key technology
that delivers biomolecules without side effects caused by excessive doses. 3D printing technologies and DDSs have been assembled
successfully, so new possibilities for improved tissue regeneration have been suggested. If the interaction between cells and scaffold
system with biomolecules can be understood and controlled, and if an optimal 3D tissue regenerating environment is realized, 3D printing
technologies will become an important aspect of tissue engineering research in the near future.
