Title:Immune Tolerance Elicited via Unique Ocular and Oral Routes
Volume: 15
Issue: 1
Author(s): H.M. Ashour
Affiliation:
Keywords:
Tolerance, ACAID, nickel, oral tolerance, T regulatory cells, cytokines.
Abstract: Immune tolerance can be induced by numerous methods. This review article aims to draw lines of
similarity and contrast between two unique models of immune tolerance, namely Anterior Chamber Associated
Immune Deviation (ACAID) and Nickel-induced oral tolerance. ACAID is an immune tolerance model that leads
to the generation of CD4+ T regulatory cells and CD8+ T regulatory cells in the periphery after the injection of
an antigen into the anterior chamber of the eye. Nickel-induced oral tolerance is another immune tolerance
model that is induced by the contact allergen Nickel and leads to the generation of Nickel-specific CD4+ CD25+
T regulatory cells after oral exposure. The goal of comparing different models of immune tolerance is to identify
which mechanisms are universal and which mechanisms are model-specific. The knowledge of such
mechanisms would allow scientists and clinicians to better intervene in different immune deregulation
scenarios.
