Title:Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications
Volume: 15
Issue: 3
Author(s): Xiaolin Wang, Nada Ben Ahmed, Gisela S. Alvarez, Maria V. Tuttolomondo, Christophe Helary, Martin F. Desimone and Thibaud Coradin
Affiliation:
Keywords:
Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.
Abstract: The sol-gel process provides a robust and versatile technology for the immobilization of biologicals.
A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins,
antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review
describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors
as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
