Title:CYLD-Mediated Signaling and Diseases
Volume: 16
Issue: 4
Author(s): Bryan J. Mathis, Yimu Lai, Chen Qu, Joseph S. Janicki and Taixing Cui
Affiliation:
Keywords:
Cardiovascular, CYLD, cylindromatosis, deubiquitination, K63, MAPK, NF-kB.
Abstract: The conserved cylindromatosis (CYLD) codes for a deubiquitinating enzyme and is a crucial
regulator of diverse cellular processes such as immune responses, inflammation, death, and proliferation.
It directly regulates multiple key signaling cascades, such as the Nuclear Factor kappa B [NFkB]
and the Mitogen-Activated Protein Kinase (MAPK) pathways, by its catalytic activity on polyubiquitinated
key intermediates. Several lines of emerging evidence have linked CYLD to the pathogenesis
of various maladies, including cancer, poor infection control, lung fibrosis, neural development,
and now cardiovascular dysfunction. While CYLD-mediated signaling is cell type and stimuli
specific, the activity of CYLD is tightly controlled by phosphorylation and other regulators such as Snail. This review explores
a broad selection of current and past literature regarding CYLD’s expression, function and regulation with emerging
reports on its role in cardiovascular disease.
