Title:Adrenomedullin in Vascular Endothelial Injury and Combination Therapy: Time for a New Paradigm
Volume: 13
Issue: 4
Author(s): Ming Yuan, Qiurong Wang, Chengxiang Li, Ling Tao, Haifeng Zhang, Haichang Wang, Yingmei Zhang and Jun Ren
Affiliation:
Keywords:
Vascular, endothelial, adrenomedullin, combination, cell signaling.
Abstract: Adrenomedullin is a highly conserved vasoactive peptide participating in a variety of
physiological and pathophysiological processes including pregnancy, embryonic development, tumor
progression and regulation of vascular tone. In particular, adrenomedullin expression is widely distributed
throughout the cardiovascular system including heart, lungs, blood vessels and kidneys. The observation
that adrenomedullin co-localizes with its receptors suggests that the peptide may act as an
autocrine and/or paracrine factor in the regulation of cardiovascular function. In this review, we described
the pathophysiological changes in plasma and local adrenomedullin associated with vascular endothelial function
and the signaling mechanisms involved. Recent evidence has depicted a unique role of adrenomedullin in the regulation of
vascular endothelial function in part through regulation of cAMP, cGMP and intracellular Ca2+ mobilization. This review
summarized vascular endothelial actions of adrenomedullin under both physiological and pathophysiological conditions in
an effort to provide guidance for the clinical application of adrenomedullin in vascular diseases.
