Title:Role of CHK2 Inhibitors in the Cellular Responses to Ionizing Radiation
Volume: 14
Issue: 10
Author(s): Mona Haddad Zahmatkesh, Seyed Jalal Hosseinimehr and Hamid Mahdiuni
Affiliation:
Keywords:
Apoptosis, CHK2 inhibitor, cancer, debromohymenialdisine, ionizing radiation, radiosensitive, radioprotective.
Abstract: Ionizing radiation is the more effective therapy to reduce tumor growth through damaging the DNA of cells. In
response to DNA damage, cells activate the checkpoint kinases such as CHK2, which signal to initiate repair processes
and cell-cycle arrest, until the damaged DNA is repaired. At present, the development of CHK2 inhibitors has provided
an interesting strategy for the treatment of cancer by introducing new radiation modifier agents. CHK2 inhibitors can
contribute for the improvement of cancer therapy through sensitizing cancerous cells and radioprotection of normal cells
against ionizing radiation. This review describes and discusses the most recent inhibitors of CHK2 and presents an
evaluation of chemical structures and biological activities. As well as their role in cell growth during exposure to ionizing
radiation.
