Title:Targeting Oncogenes and Tumor Suppressors genes to Mitigate Chemoresistance
Volume: 14
Issue: 7
Author(s): Tahereh Fatemian and Ezharul Hoque Chowdhury
Affiliation:
关键词:
Akt， Bcl-2，癌症，化疗耐药性，Her2， MAPK，癌基因， P53，生存素，靶向治疗，肿瘤抑制
摘要: Malfunctions in membrane transporters or disruptions in signaling cascades induce resistance to chemotherapy
in cancer cells resulting in treatment failure. To adjust the genetic alterations leading to these cellular protective measures,
dissection and verification of the contributing routes would be required. In justification of knockdown of the key genes,
RNA interference provides a reliable probing tool, enabling exploration of phenotypic manifestation of targeted genes.
Investigation of the non-transporter targets, predominantly oncogenes and tumor suppressor genes, by means of small
interfering RNA with the aim to re-sensitize cancer cells to therapeutics will be discussed in this review.
