Title:Reduction of Hyperproduction of Thyroid Autoantibodies in Patients without Disturbance of the Thyroid Function: New Patents
Volume: 8
Issue: 2
Author(s): Borys A. Gerasun, Olga A. Holubovska, Roman Y. Hrytsko, Olexandr N. Zinchuk and Andrij V. Shkurba
Affiliation:
Keywords:
Autoimmune process, autoleukocytes, immunization, thyroid autoantibodies, thyroglobulin antibodies, thyroperoxidase.
Abstract: A new method of reduction of autoimmune process activity related to the thyroid in patients without signs of
thyroiditis is presented in the article (patent of Ukraine No. 103742). New patents and inventions from different countries
of the world related to the problem have been analysed. Materials and Methods: Sixty one patients with a significant disturbance
of tolerance to the thyroid antigens in the absence of disturbance of the thyroid function were involved in the research.
Twenty two patients with chronic hepatitis C, genotype 1 HCV, receiving antiviral therapy, were also included in
the research. Patients were immunized intracutaneously with autoleukocytes for autoimmune process inhibition. After
single immunization with autoleukocytes decrease in the level of antibodies against the thyroid antigens was observed in
all patients. In some patients without chronic hepatitis C the levels of thyroperoxidase and thyroglobulin antibodies decreased
by 50% and more (33.33% and 20.51%, respectively). In patients with ChHC these indices were considerably
lower, and the duration of the achieved effect was shorter. However, immunization inhibited activity of immune process
in patients with ChHC due to interferon therapy. The suggested method enables to decrease the threat for thyroiditis development
even in patients with chronic hepatitis C during antiviral therapy.
