Title:MicroRNAs and Cancer; an Overview
Volume: 15
Issue: 5
Author(s): Lutfi Tutar, Esen Tutar and Yusuf Tutar
Affiliation:
Keywords:
Biomarkers, cancer, microRNAs, therapeutics.
Abstract: MiRNAs are a family of small, endogenous, and evolutionarily conserved non-coding ribonucleic acids that
have been involved in the regulation of several essential, cellular, and functional processes. MicroRNAs are known to
play key roles in all types of cancer and function as oncogenes (oncomirs) or tumour-suppressors in up-regulation or
down-regulation processes respectively. MiRNAs have potential power to be examined as prognostic and diagnostic biomarkers.
Modulating miRNAs, based on two major approaches (miRNA mimics and miRNA antagonists), is used for
clinical development of therapeutic miRNAs. This review emphasizes the latest discovery in the field of miRNA research
involved in cancer, biomarkers, and therapeutics.
