Title:Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry
Volume: 18
Issue: 16
Author(s): Aziza Saber, Hamid Marzag, Rachid Benhida and Khalid Bougrin
Affiliation:
Keywords:
[2+2] cycloaddition, 1, 3-dipolar cycloaddition, carbocycles, diels-alder, green catalysis, green chemistry, heterocycles, microwave
synthesis.
Abstract: Recent developments in the microwave-assisted synthesis of carbo- and heterocyclicsystems are reviewed with the focus on
diversity-oriented cycloaddition reactions. Ineed, these reactions represent one of the most important endeavors in chemistry and are of
considerable interest in the synthesis of carbo-and heterocyclic compounds from simple unsaturated systems, and allow the creation of
more than two bonds in one step. This review summarizes recent literature (2006-2013) on advances regarding [3+2], [4+2] and [2+2]
cycloadditions including their miscellaneous version. Advantages of microwave dielectric heating are highlighted by comparison with
conventional thermal conditions. In particular, we describe here the microwave effect, reaction media including solvent-free transformations
and more ecological processes in the context of green and environmentally benign chemistry.
