Title:Oxidative Stress: Meeting Multiple Targets in Pathogenesis of Diabetic Nephropathy
Volume: 15
Issue: 5
Author(s): Mandeep Kumar Arora and Umesh Kumar Singh
Affiliation:
Keywords:
Anti oxidants, diabetic nephropathy, oxidative stress, ROS generation, signaling pathways, target site.
Abstract: Excessive production of reactive oxygen species is an important mechanism underlying the pathogenesis of
diabetes associated macrovascular and microvascular complications including diabetic nephropathy. Diabetic nephropathy
is characterized by glomerular enlargement, early albuminuria and progressive glomerulosclerosis. The pathogenesis of
diabetic nephropathy is multi-factorial and the precise mechanisms are unclear. Hyperglycemia-mediated dysregulation of
various pathways either enhances the intensity of oxidative stress or these pathways are affected by oxidative stress. Thus,
oxidative stress has been considered as a central mediator in progression of nephropathy in patients with diabetes. In this
review, we have focused on current perspectives in oxidative stress signaling to determine common biological processes
whereby diabetes-induced oxidative stress plays a central role in progression of diabetic nephropathy.
