Title:Role of Centrosome in Regulating Immune Response
Volume: 15
Issue: 5
Author(s): Ambuj Kumar, Vidya Rajendran, Rao Sethumadhavan and Rituraj Purohit
Affiliation:
Keywords:
Centrosomes, immune system, immunological synapse.
Abstract: Centrosomes are the vital component of cell cycle progression pathway. Recent investigations have suggested
their role in regulating the immune response system. Centrosome polarization delivers secretory granules to the immunological
synapse (IS). The Cytotoxic T lymphocytes use a specific mechanism, controlled by centrosome delivery to the
plasma membrane for delivering the secretory granules to the immunological synapse. Moreover, the polarization of centrioles
to the immunological synapse directs secretion from cytolytic cells of innate as well as adaptive immune systems.
Although the recent investigations have suggested their strong role in mediating the crucial events of immunological response,
there are few discrepancies that are yet to be resolved. Furthermore, a clear picture of their molecular mechanism
along with their cellular functions has not been reported. In this manuscript we have reviewed some important points that
explain the importance of centrosomes in mediating the immunological signals and the delivery of lytic discharge from
the cytotoxic and killer cells.
