Title:The Relationship between Inflammatory and Oxidative Stress Biomarkers, Atherosclerosis and Rheumatic Diseases
Volume: 20
Issue: 4
Author(s): Corina Serban and Simona Dragan
Affiliation:
Keywords:
Biomarkers, atherosclerosis, screening, cardiovascular risk, circulating biomarkers, rheumatic diseases, oxidative stress, inflammation.
Abstract: Atherosclerotic cardiovascular disease is the leading cause of death in many developed countries. It is characterized by complex
endocrine, paracrine and juxtacrine interactions between immune and vascular cells, as well as several tissues and organs. Oxidative
stress and inflammation have an important role in the promotion of atherosclerotic cardiovascular disease. Considering the complicated
mechanisms and signals involved in atherosclerosis, research is focused on blood-based biomarkers, gene-based markers, metabolomics
and other potentially interesting approaches for biomarker discovery. These biomarkers can be introduced as routine diagnostic tests if
they prove to be cost-effective and to predict future cardiovascular events. Given the overlap of circulating inflammatory and oxidative
stress biomarkers in atherosclerosis and rheumatic diseases, we aim to overview their potential to screen cardiovascular risk and also to
predict the evolution of associated rheumatic diseases.
