Title:Naturally Occurring Methyl Salicylate Glycosides
Volume: 14
Issue: 1
Author(s): Ping Mao, Zizhen Liu, Meng Xie, Rui Jiang, Weirui Liu, Xiaohong Wang, Shen Meng and Gaimei She
Affiliation:
Keywords:
Analgesic, anti-inflammation, antipyretic, methyl salicylate glycoside, NSAIDs.
Abstract: As an important part of non steroids anti-inflammation drug (NSAIDs), salicylate has developed from natural
substance salicylic acid to natrium salicylicum, to aspirin. Now, methyl salicylate glycoside, a new derivative of salicylic
acid, is modified with a -COOH group integrated one methyl radical into formic ether, and a -OH linked with a
monosaccharide, a disaccharide or a trisaccharide unit by glycosidic linkage. It has the similar pharmacological activities,
anti-inflammatory, analgesic, antipyretic and antithrombotic as the previous salicylates’ without resulting in serious side
effects, particularly the gastrointestinal toxicity. Owing to the superiority of those significant bioactivities, methyl
salicylate glycosides have became a hot research area in NSAIDs for several years. This paper compiles all 9 naturally
occurring methyl salicylate glycosides, their distribution of the resource and pharmacological mechanism, which could
contribute to the new drug discovery.
