Title:Cardiovascular and Antidipsogenic Effects of Nesfatin-1
Volume: 19
Issue: 39
Author(s): Gina L.C. Yosten and Willis K. Samson
Affiliation:
Keywords:
Arterial pressure, sympathetic nervous system, hypothalamus, medulla, thirst, appetite.
Abstract: Nesfatin-1, derived from the nucleobindin-2 gene product, is expressed in neurons located in brain centers known to be important
in the central regulation of both cardiovascular function and fluid and electrolyte homeostasis. In fact the peptide colocalizes in those
neurons with an impressive list of neuropeptides and neurotransmitters known to be important in the regulation of thirst, appetite and central
autonomic control. We and others have demonstrated potent sympatho-stimulatory actions of nesfatin-1 in brain and the potential
physiologic relevance of those effects. In addition, although nesfatin-1 was originally described as a peptide with potent anorexigenic actions
in brain, effects corroborated by several groups, it is possible that the anorexigenic actions of nesfatin-1 are secondary to a primary
action to reduce thirst. Progress in unraveling the importance of endogenous nesfatin-1 in cardiovascular function, or fluid and electrolyte
homeostasis, has been limited due to the to date unavailability of nesfatin-1 antagonists and the fact that the receptor for nesfatin-1 remains
unidentified.
