Title:Antibody-Targeted Immunoliposomes for Cancer Treatment
Volume: 13
Issue: 14
Author(s): Jie Gao, Huaiwen Chen, Hao Song, Xiao Su, Fangfang Niu, Wei Li, Bohua Li, Jianxin Dai, Hao Wang and Yajun Guo
Affiliation:
Keywords:
Antibody engineering, Antibodies conjugation, Immunoliposomes, Gene therapy, Chemotherapy, Cancer.
Abstract: Monoclonal antibodies (mAbs) or their derivatives are often used as the targeted ligands in the ligand targeted
liposomes (LTLs). LTLs modified with mAbs or their derivatives are defined as immunoliposomes. Immunoliposomes
can be designed to improve the pharmacological properties of conventional drugs. The development of immunoliposomes,
which perfectly combines antibody engineering and liposomes, is becoming a possible state-of-the-art in liposome
research. This review discusses the recent characterization and therapeutic effects of immunoliposomes in cancer therapy.
The recent advances in the field of immunoliposomes for the treatment of cancer are summarized as follows: antibody
engineering, current antibody conjugation strategies, characterization and therapeutic effects of immunoliposomes and the
future perspective of immunoliposomes. Although antibody targeted immunoliposomes are being developed rapidly, there
has been still a number of hot spots in research that require sustained effort for success. It is reasonable to predict that
immunoliposomes will be approved for clinic use, and patients will benefit much from this cancer targeted therapy.
