Title:Recombinant Therapeutic Protein Vaccines
Volume: 20
Issue: 12
Author(s): Satoshi Ohtake and Tsutomu Arakawa
Affiliation:
Keywords:
Recombinant proteins, therapeutic proteins, vaccines, expression systems.
Abstract: Recombinant technology has ushered in a new era for the pharmaceutical industry. Protein therapeutics, including
plasma-derived products and antibodies obtained from the serum of infected patients, have been successfully adopted
and utilized to treat various indications. The development of recombinant technology and the subsequent improvement in
expression, purification, and formulation technologies have enabled the generation of highly purified proteins in a scalable
and cost-effective manner. The discovery and development of several recombinant proteins, such as growth factors and
cytokines, will be described followed by a brief review of monoclonal antibodies and enzyme replacement therapy. Recombinant
protein-based vaccine, which is the focus of the current review, is described in detail with particular emphasis
on several viral and bacterial infections. Challenges and new approaches in their use as a replacement for the currently
available vaccines are discussed.
