Title:Apolipoprotein E Derived Peptides Inhibit the Pro-Inflammatory Effect of Lysophosphatidylcholine
Volume: 21
Issue: 2
Author(s): Sunil A. Nankar, Jitendra S. Prajapati and Abhay H. Pande
Affiliation:
Keywords:
Apolipoprotein-derived peptide, circular dichroism, fluorescence spectroscopy, inflammation, lysophosphatidylcholine,
qRT-PCR.
Abstract: Apolipoprotein-derived peptides have emerged as a potential candidate for the treatment of various inflammatory
disease conditions. These peptides bind to pro-inflammatory lipids and inhibit their inflammatory functions. Lysophosphatidylcholine
(LPC) is a potent pro-inflammatory lipid and increased level of circulating LPC plays a major role
in various acute and chronic inflammatory conditions. In this report we examined the effect of peptides derived from the
C-terminal domain of human apolipoprotein E on the properties of LPC. Our results show that the peptides (E8, E10 and
E11) bind to LPC and inhibit LPC-induced up-regulation of pro-inflammatory markers in human leukocytes. The results
suggest that these peptides can be used as an anti-inflammatory agent in inflammatory conditions in which increased level
of LPC is a culprit.
