Title:Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives
Volume: 11
Issue: 2
Author(s): Wang Liju and Keyume Ablajan
Affiliation:
Keywords:
Dihydropyrano[2, 3-c]pyrazole, multi-component reactions, one-pot synthesis, Pyrrolidine, Triazolo[4, 3-a]pyrimidines.
Abstract: Pyrrolidine was used as a catalyst for the simple, convenient, and highly efficient synthesis of dihydropyrano[2,3-c]pyrazole
derivatives. Four-component one-pot reactions of β-ketoester, hydrazine, ethyl glyoxalate or ethyl pyruvate, and malononitrile in ethanol
under reflux conditions led to excellent yields of 79%-94%.