Title:2-Aminoimidazoles in Medicinal Chemistry
Volume: 13
Issue: 13
Author(s): AleŠ Žula, Danijel Kikelj and Janez Ilaš
Affiliation:
Keywords:
2-aminoimidazole, alkaloids, lead compounds, marine compounds, medicinal chemistry, scaffold, secondary
metabolites.
Abstract: 2-Aminoimidazole skeleton represents a unique building block which is often used in the design of modulators
of different targets and small molecule drugs. Alkaloids isolated from marine sponges are known to be one of the most
common sources of the 2-aminoimidazole compounds and from a medicinal chemistry perspective, the marine alkaloids'
fascinating structures as well as their broad spectrum of pharmacological activity make them promising lead compounds
for various druggable targets. This review will focus on the presentation of biologically evaluated 2-aminoimidazole
compounds showing a variety of pharmacological properties and their structure-activity relationship. The importance of
2-aminoimidazoles as bioisosteres of guanidine, acylguanidine, benzamidine and triazole groups will be highlighted.
