Title:Effectivity of Long Antigen Exposition Dendritic Cell Therapy (LANEXDC®) in the Palliative Treatment of Pancreatic Cancer
Volume: 20
Issue: 38
Author(s): F. Gansauge, B. Poch, R. Kleef and M. Schwarz
Affiliation:
Keywords:
Cancer, dendritic cells, immunotherapy, LANEX-DC®, pancreas.
Abstract: Purpose: In pancreatic cancer median survival times range around 6, 6 to 6,9 months. Here we retrospectively
analyzed the outcome of immunotherapy in the additional palliative treatment of pancreatic cancer with long antigen exposition
dendritic cell therapy (LANEX-DC®) in 138 patients who were treated at our institution. Patients: Data were
available of 134 patients (97.1%). The median interval between first diagnosis and start of treatment was 1.4 months.
Results: Therapy was well tolerated and no serious side effects were observed. The survival rate after 6 months was 72.2
% and afters 9 month 50.4%. The median survival time according to Kaplan- Meier regression analysis was 8.9 months.
Median survival was significantly higher in the group of patients who started immunotherapy within 2 months following
diagnosis (p=0.029) or repeated immunotherapy (p=0.027). Interestingly, younger patients <= 60 years of age lived significantly
longer as patients > 60 years of age (p = 0.022). Conclusion: We were able to demonstrate in a large retrospective
analysis that additional treatment with dendritic cells (LANEX-DC®) is highly effective and extends the median survival
times up to 8.9 months. Furthermore we were able to demonstrate that median survival can be increased by early beginning
and repetition of LANEX-DC® treatment.
