Title:Altered Glial Plasticity in Animal Models for Mood Disorders
Volume: 14
Issue: 11
Author(s): Boldizsár Czéh, Eberhard Fuchs and Gabriele Flügge
Affiliation:
Keywords:
Astrocyte, adult neurogenesis, depression, hippocampus, microglia, oligodendrocyte.
Abstract: Numerous clinical evidences support the notion that glial changes in fronto-limbic brain areas could contribute
to the pathophysiology of mood disorders. Glial alterations have been reported not only in patients, but also in various
kinds of animal models for depression. Molecular and cellular data suggest that all the major classes of glial cells are affected
in these conditions, including astrocytes, oligodendrocytes, NG2-positive cells and microglia. The aim of this review
was to summarize the currently available experimental results demonstrating alterations in glial morphology and
functioning in animal models for mood disorders. Better understanding of these glial changes affecting neuronal activity
could help us to identify novel targets for the development of antidepressant drugs.
