Title:The Effect of Adult and Pediatric Cardiopulmonary Bypass on Pharmacokinetic and Pharmacodynamic Parameters
Volume: 8
Issue: 4
Author(s): Annewil van Saet, Saskia N. de Wildt, Catherijne A.J. Knibbe, Ad J.J.C. Bogers, Robert J. Stolker and Dick Tibboel
Affiliation:
Keywords:
Anesthesiology, cardiac surgery, cardiopulmonary bypass, pediatric, pharmacodynamics, pharmacokinetics.
Abstract: Cardiopulmonary bypass (CPB) is known to have important effects on the disposition of drugs, which in turn
may have important implications for the efficacy and toxicity of drug therapy. These effects constantly change throughout
CPB and some continue to exert influence after the patient has been successfully weaned. In children, developmental
and disease specific changes in drug disposition and effect also need to be taken into account when studying the effects
of CPB.
This review will provide an extensive overview of the current literature concerning the mechanisms behind the effects
CPB has on pharmacokinetic and pharmacodynamic parameters. Also the effects of CPB on individual anesthetic drugs
and sedatives, opioids, neuromuscular blocking agents, antibiotics and miscellaneous medications will be reviewed.
Special attention will be paid to the pediatric population.
