Title:Modulation of Neutrophil Development and Homeostasis
Volume: 13
Issue: 8
Author(s): G. Liu, H. Yang, X. Chen, X. Wang and Y. Chu
Affiliation:
Keywords:
Development, differentiation, granulocytopoiesis, homeostasis, immunity, mechanisms, modulation,
neutrophils.
Abstract: Neutrophils are highly motile phagocytic cells that constitute the first line of defense of the innate
immune system. Unlike the other innate immune cells, mature neutrophils fully equipped with an armory of
granules are short lived cells which are differentiated and programmed from hematopoietic stem cells in the
bone marrow. In blood, mature or nearly mature cells are devoid of proliferative potential. While the killing
mechanisms of neutrophils have been the research focus in the past, attention was then directed toward
granulocytopoiesis by the recent studies about the specfic functional states and exact regulatory mechanisms
in neutrophil development and homeostasis. Here, we focus on the recent findings regarding the mechanisms
that control the generation and homeostasis of neutrophils.
