Title:From Target Therapy to miRNA Therapeutics of Human Multiple Myeloma: Theoretical and Technological Issues in the Evolving Scenario
Volume: 14
Issue: 10
Author(s): Marco Rossi, Nicola Amodio, Maria Teresa Di Martino, Daniele Caracciolo, Pierosandro Tagliaferri and Pierfrancesco Tassone
Affiliation:
Keywords:
Bone disease, microRNA, miRNA, multiple myeloma, non coding RNA, target therapy
Abstract: The progress in the understanding of biological events underlying multiple myeloma (MM) development and
progression has allowed the design of molecularly targeted therapies (MTTs) for this disease and several new compounds
are presently under investigation in the preclinical and clinical settings. The recent discovery that miRNAs, and short non
coding RNAs in general, are involved in the pathogenesis of cancer has raised the issue whether a novel therapeutic approach
should be provided by selective interference with miRNA network. This review will focus on the rationale of
miRNA-based therapeutics, providing the most relevant information on biogenesis and technical issues in miRNA analysis.
Finally, a detailed overview of the recent findings on miRNA therapeutics of MM will be discussed.
