Title:Driven Hematopoietic Differentiation of Embryonic Stem Cells: Epigenetic Perspectives
Volume: 20
Issue: 11
Author(s): Lenka Tesarova, Stanislav Stejskal and Irena Koutna
Affiliation:
Keywords:
Epigenetic, stem cells, pluripotency, cell differentiation, hematopoietic development.
Abstract: Hematopoietic progenitors derived from human embryonic stem cells (hESCs) present both a potential cell source for cellreplacement
therapies and an in vitro model for hematopoietic stem cell (HSC) development. Current protocols for the hematopoietic differentiation
of hESCs suffer from low efficiency and functional defects in the derived HSCs. Epigenetic mechanisms of HSC development
should be addressed to overcome these imperfections. The focus of this review is to summarize the knowledge on the epigenetic
regulation of pluripotency and lineage-specific genes with the emphasis on the hematopoietic cell lineage. The potential utilization of this
knowledge to improve the generation of HSCs for clinical application is also discussed.
