Title:Nociceptinergic System as Potential Target in Parkinson’s Disease
Volume: 13
Issue: 10
Author(s): Kornelia Tekes, Saeed Tariq, Ernest Adeghate, Rudolf Laufer, Farzad Hashemi, Afshan Siddiq and Huba Kalasz
Affiliation:
Keywords:
Animal models of Parkinson’s disease, antiparkinsonian effect, medicinal chemistry data, NOP receptor
antagonists, logP, TPSA.
Abstract: Nociceptinergic system has become an important target for drug development since the identification of the
“orphan”, opioid-like-1 receptor and the isolation of its endogenous agonist nociceptin. Involvement of nociceptinergic
system has been verified in a wide range of pathophysiological processes. A large number of nociceptinergic agonists and
antagonists with peptide and non-peptide structures have been developed. Several non-peptide nociceptinergic antagonists
have recently shown effective on different animal models of parkinsonism. Neuropharmacological background for
antiparkinsonian effect of nociceptinergic antagonists, experimental models with high predictive value, nociceptinergic
antagonists shown to have potential effect in Parkinson’s disease are summarized. Medicinal chemistry data (logP and
TPSA) of the NOP receptor antagonists which are found to be effective in animal models of Parkinson’s disease are
provided.
