Title:Role of C Reactive Protein (CRP) in Leptin Resistance
Volume: 20
Issue: 4
Author(s): Marta Letizia Hribal, Teresa Vanessa Fiorentino and Giorgio Sesti
Affiliation:
Keywords:
Leptin, CRP, cardiovascular disease, leptin resistance.
Abstract: Increased plasma levels of both leptin and C reactive protein (CRP) have been reported in a number of conditions, including
obesity, and have been linked to cardiovascular pathophysiological processes and increased cardiovascular risk; interestingly these two
biomarkers appear to be able to reciprocally regulate their bioavailability, through complex mechanisms that have not been completely
clarified yet. Here we first review clinical evidence suggesting not only that the circulatory levels of CRP and leptin show an independent
correlation, but also that assessing them in tandem may result in an increased ability to predict cardiovascular disease. We summarize
also molecular studies showing that leptin is able to promote CRP production from hepatocytes and endothelial cells in vitro and discuss
the studies addressing the possibility that in vivo leptin administration may be able to modulate plasma CRP levels. Furthermore, we describe
two studies demonstrating that CRP directly binds leptin in extra-cellular settings, thus impairing its biological actions. Finally we
report genetic evidence that common variations at the leptin receptor locus are associated with CRP blood levels. Overall, the data reviewed
here show that the chronic elevation of CRP observed in obese subjects may worsen leptin resistance, contributing to the pathogenesis
of cardiovascular disease, and highlight a potential link between conditions, such as leptin resistance and endothelial dysfunction,
that may be amenable of pharmacological treatment targeted to the disruption of leptin-CRP interaction.
