Title:Combined Dyslipidemia: Should the Focus be LDL Cholesterol or Atherogenic Dyslipidemia?
Volume: 19
Issue: 21
Author(s): Manfredi Rizzo, Marcin Barylski, Ali A. Rizvi, Giuseppe Montalto, Dimitri P. Mikhailidis and Maciej Banach
Affiliation:
Keywords:
Combined dyslipidemia, cholesterol, low-density lipoprotein-cholesterol, small, dense low-density lipoprotein, high-density lipoprotein-
cholesterol, non-high-density lipoprotein-cholesterol.
Abstract: As the population becomes more obese and the prevalence of diabetes and the metabolic syndrome increases, low-density
lipoprotein-cholesterol (LDL-C) may lose its value as a sole predictor for cardiovascular risk among lipids. Combined dyslipidemia is
typically characterized by elevations in LDL-C and triglyceride levels, often accompanied by decreased high-density lipoproteincholesterol
(HDL-C) concentrations and increased levels of small, dense LDL. This common disorder results from overproduction of hepatically
synthesized apolipoprotein B in very low-density lipoproteins. In the last few years most of the international scientific guidelines
as well as several expert panels have confirmed that LDL-C represents the primary or even the only target of treatment. Yet, increasing
evidence suggests moving away from a LDL-C target-based approach to a more tailored treatment approach. For example, non-
HDL-C has been introduced in the last few years as a target of treatment.
